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Watch out folks, because Netflix is gearing up to release the latest season of its unapologetically raunchy, over-the-top pre-teen hormone romp of an animated seriesBig Mouth. The adult animated series is known for its love of foul language, human sex organs, and unashamedly tackling the topic of hormones and puberty in a hilarious and occasionally heartwarming fashion. Now, with Season 6 on the horizon, it’s about time we recapped everything we know so far aboutBig MouthSeason 6, which will be released on October 28th, 2022.
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Watchthe Big Mouth Season 6 Trailers
In the teaser, Hormone Monster Connie (Maya Rudolph) is swiping through Instagram, checking out pictures of her crush: actorSeann William Scott. Maury (Nick Kroll) enters the room asking her to rub cocoa butter on his pregnancy belly. After some back and forth, the shot ends with Connie screaming and then a cut to the Netflix logo, along with the release date of Season 6 ofBig Mouth. Although short on content, the teaser actually was crucial in solidifying one huge question that viewers had going into Season 6. For confused viewers, Maury’s pregnancy may come as a surprise. That’s because the pregnancy storyline between Maury and Connie actually comes directly from the end of theBig Mouthspinoff seriesHuman Resources, which debuted on Netflix earlier this year. The series explored the behind-the-scenes world of the series’ monsters as they assist various humans in navigating the human experience. During the teaser, Maury and Connie explicitly break the fourth wall to address that yes, the events ofHuman Resourcesdo, in fact, carry over to the events ofBig Mouth. This means that the two series are taking place concurrently, and there’s an established continuity within the expanding universe of theBig Mouthfranchise.
The full trailer for the sixth season ofBig Mouthwas released by Netflix on August 01, 2025. Set to theSister Sledgeclassic hit “We Are Family” the trailer begins once again revealing Maury’s pregnancy. The trailer then shows that the pubescent middle-schoolers have gotten the results back of their DNA tests, Lola learns she has three dads, Jay discovers he has a secret half-brother and Nick realizes that his grandpa was a famous ‘nipple-twisting champion.’ Other scenes of the trailer include a tease at an homage toBridgerton, Jessi at odds with her new baby half-sister, and an incredibly awkward webcam encounter involving Andrew and his parents, and his love interest from the previous season Bernie Sanders (no, not the US senator from Vermont).
When is Big Mouth Season 6 Coming Out?
Season 6 ofBig Mouthis slated to release on Friday, October 28th, 2022. The general release of Season 6 should come as no surprise to viewers of the show, as the show has been airing each season roughly around the same time each year. Season 6 was actually announced back in the Fall of 2019 while Season 3 was still airing.
Big Mouthis one of the more commercially and critically successful animated shows coming from Netflix, with a 99% on Rotten Tomatoes and consistent season debuts in the Netflix Top 10 internationally, and the Number 1 spot in the United States. It is Netflix’s most popular adult animated comedy series. Fans of the show will be happy to learn that prior to the airing of Season 6,Big Mouthhas already been renewed for Season 7.Furthermore, its spinoff seriesHuman Resourceshas been picked up for Season 2.
Who Is Returning In Big Mouth Season 6? Who’s New?
Luckily, the core cast ofBig MouthSeason 6 remains largely unchanged from Season 5. The main cast and their respective characters (In some cases this is quite a few) are listed below:
Nick Kroll as Nick/Maury the Hormone Monster/Coach Steve/Rick the Hormone Monster/Lola
John Mulaneyas Andrew/Mint/Grandpa Andrew/Babe the Blue Ox/Detective Florez
Jessi Kleinas Jessi
Jason Mantzoukasas Jay/Guy/Socrates
Ayo Edebirias Missy
Fred Armisenas Elliot Birch/Stavros/Bob the Hormone Monster
Maya Rudolph as Connie the Hormone Monstress/Diane/Bonnie the Hormone Monster
Jordan Peeleas Ghost of Duke Ellington/Freddie Mercury/David Bowie/Prince
Andrew Rannellsas Matthew MacDell
Paula Pellas Barbara Glouberman
Richard Kindas Marty Glouberman
Thandiwe Newtonas Mona the Hormone Monster
Ali Wongas Ali
One thing thatBig Mouthhas become known for is its inclusion of A-List actors as guest voice actors on the show. Some appearances from seasons past includePaul Giamatti,Jon Hamm, the stars ofQueer Eye, and many other recognizable talents. This season it remains to be seen who they will bring on as guests, but keep those ears tuned in for familiar voices.
Another question that comes to mind is connected to the teaser announcement, which confirmed the continuity betweenBig Mouthand its spinoff seriesHuman Resources.WithHuman Resourcesintroducing viewers to beloved voice actors likeRandall Parkas Pete the Logic Rock andHugh Jackmanreturning to the universe as Dante the Addiction Angel, there is a possibility that we will see some of the characters that were introduced inHuman Resourcesmake appearances in Season 6 ofBig Mouth. This wouldn’t be unprecedented, as many of the creatures fromBig Mouthplayed important roles inHuman Resources. We even got a cameo from Andrew in the spinoff series. This crossover potential is something that viewers should look out for moving forward between the two shows.
Related:7 Best Friendships in the ‘Big Mouth’ Universe (That Aren’t Nick & Andrew)
What is the Background Behind Big Mouth?
Big Mouthwas created by the team of Andrew Goldberg, Nick Kroll,Mark Levin, andJennifer Flackettand is released on the Netflix streaming platform. The four serve as executive producers along withBlair Fetter,Kristen Zolner, andJane Wiseman. Season 1 ofBig Mouthpremiered on Netflix on August 04, 2025. The series is based on the experiences of Nick Kroll and Andrew Goldberg, who both grew up as childhood friends in an upper-middle-class neighborhood in suburban Westchester County, NY.
What Is the Plot of Big Mouth Season 6?
Big Mouthrevolves around a group of young teenagers as they struggle with aspects of puberty and adolescence. Throughout these struggles, they are aided by various creatures that represent different aspects of the experience, including Hormone Monsters, Anxiety Mosquitos, Depression Kitties, and Shame Monsters.
Season 5 introduced a number of plot points and developments for our leading characters which will undoubtedly continue to be explored during Season 6. The season saw Andrew dealing with an unrelenting amount of horniness, and learning how to be more comfortable and confident in his own skin. Meanwhile, Nick navigates his broken heart after Jessi renounces his affection for her. He develops a Hate Worm but eventually is encouraged to overcome it by the non-animated grown-up version of himself played also by Nick Kroll. Meanwhile, Jessi explores her sexuality and falls in love with Ali. Unfortunately, she forgets to devote time to her other personal relationships, especially with Missy. Because of this and her romantic struggles with Devon, Missy spends much of the season harboring a Hate Worm. This Hate Worm eventually turns into a Love Bug, as she learns to express her feelings, build her own confidence, and communicate with her family and friends in a more healthy way. Lastly, Jay is exploring his sexuality as well. Although he finds himself in a toxic rekindled romance with Lola, he chooses to start dating Mathew in the hopes of finding a more emotionally stable relationship.
The ending of Season 1 ofHuman Resourcesmay have some bearing on Season 6 ofBig Mouthas well. The teaser confirms that both series are happening concurrently and in the same universe. AlthoughHuman Resourcescenters around the world of monsters, many of these monsters appear inBig Mouthas well, and developments for their characters should carry over between shows. One development that could have an impact on the narrative of Big Mouth’s Season 6 is the developing pregnancy of Maurice at the hands of Connie. We could also see the appearances of characters introduced inHuman ResourcesinBig Mouth, which could provide a jolt to the season’s plot lines. Whatever the case, Season 6 finds our main characters growing and exploring themselves further, whether that’s through sexuality, relationships, confidence, or communication.
